Scope of NMR Applications in Basic Research and Industry

NMR has established itself as a powerful tool in the hands of analytical scientist. It provides valuable structural details on small organic molecules, natural products, man- made synthesized materials, large biomolecules and other complex molecular entities with masses ranging upto around 100000 daltons.

X射线晶体学和NMR光谱相互补充，并提供与结构细节和原子取向相关的信息。

Detailed applications and methods can be accessed in treatises and reference manuals. The objective of this article is to provide you an insight into the potential applications of NMR in basic research and industry.

研究应用

\(^1H\) NMR is popular to this day in University laboratories and research establishments. Availability of bench top models has contributed further to the acceptaibility of the technique. However, high end research applications demandhigh frequency superconducting NMR magnet systems. Such systems require elaborate infrastructure and additional安全规范and recurring cost of cryogenic fluids.

典型的研究应用程序包括:

结构阐明

NMR is a powerful , reliable and a mature technique for structural identification of both natural and synthetic origin molecules including polymers and biomolecules.

Intermolecular interactions

NMR permits studies on weak molecular interactions including hydrogen bonding between inter molecular functional groups and other molecules present.

分子动力学和蛋白质折叠

NMR是针对大型生物分子和蛋白质折叠/展开机制的分子动力学研究的强大技术。

Membrane studies

NMR允许在天然膜环境中蛋白质的原子水平结构测定，还提供有关蛋白质 - 配体相互作用的信息

Enzymatic Interactions

有用的构象研究对于与酶结合的化合物有助于理解生化过程机制。

Industrial applications

工业实验室通常使用\（^1H \）NMR系统。高频超导磁铁的系统在工业环境中并不常见，因为需要高技能的操作员，特殊的基础设施和更高的重复成本。典型的应用包括药品，食品，石油产品和聚合物合成材料

食物

NMR is finding increased applications in food processing and surveillance of confiscated food specimens. Studies relate to qualitative analysis of both target compounds as well as suspected prohibited constituents. NMR also serves as a rapid routine confirmation to the findings of other complimentary techniques such as spectroscopy and chromatography.

Pharmaceuticals

NMR has immense potential in drug development and screening applications. Such studies are also extended to monitoring conformations of drug molecules bound to receptors and proteins.

Polymers & Synthetic materials

TG-NMR contributed to information on micro structure details of poly- olefins over a range of temperatures. Multinuclear studies such as \(^1^3C\) NMR provide valuable information on microstructures of polymers and co-polymers. The studies are extended to other engineering polymers for estimations of impurities, contaminants and degradation products that contribute to ageing effects of such materials.

NMR has proved to be a valuable asset in both academic research and industrial laboratories. NMR imaging is another field which has made significant contributions in medical diagnosis and will be covered in a subsequent article.