仪器校准对结果质量的重要性

You must have heard about the importance of calibration for laboratory equipment, but do you really understand its value? While this is a widespread and vital concept, there are people who still do not know its meaning or significance. Here, we will help you understand everything about calibration, from what calibration is to why is calibration important.

What Is Calibration?

Even before you get to thepurpose of calibration in the laboratory, you first need to understand what this process is and why it is performed in various places.

校准基本上是一个过程，您可以比较正在测试的设备（DUT），该设备具有未知值，并具有已知值的参考标准。通过此，您可以注意任何错误，以进一步纠正设备以获得准确的结果。

Mostly, a calibration process is carried out when the machine or tool is new. As it just came in from the manufacturer, there are high chances of it being not showing perfect results. Calibration helps in correcting the machine so that no errors are found in its measurement values.

However, calibration is not a one time process. It is carried out again on a pre-determined frequency to check for errors that may occur due to the equipment’s wear and tear. Therefore, ensuring that the measurement tool shows the correct values all the time, and no procedure gets affected by it.

Calibration is usually crucial for the following industries:

• Laboratories:Thepurpose of calibration in the laboratoryis to ensure all their tests are carried out properly, and no instrument causes any inaccuracy.
• Food Industry:Thesignificance of calibration在食品行业中，将其成分保持在标准限制之内，并避免消费者或品牌的任何严重麻烦。
• Manufacturing Units:Theimportance of calibrationincreases for manufacturing units维护其流程，警报和系统。另外，它有助于消除工人的任何伤害或损失。

Out of all, laboratory equipment calibration is what we will focus here on.

Why Is Calibration Important?

Instrument calibration is a vital activity without which your results cannot be relied upon.

Your lab may be equipped with the most sophisticated and costly instruments but if you do not calibrate them periodically, your results will have no significance.

Even low-cost instruments such as thermometers, pH meters, volumetric apparatus and ovens need to be calibrated from time to time to give reliable data.

重量，测量杆，体积设备等物品显然不会随时间而变化，不仅在购买时，而且定期按定义的间隔进行校准。

The need for such calibration arises due to changes in environmental conditions such as temperature, humidity and improper handling leading to wear and tear.

Sophisticated instruments running on mains power supply need to be more frequently calibrated because of involvement of several variables such as stability of power supply, usage lifetime of light sources, fall in efficiency of chromatography columns, normal wear and tear of mechanical parts,etc.

仪器校准始终符合可追溯的标准，该标准在指定的环境条件下保持。需要对已知的国家和国际标准化机构（例如ISO，NIST，ASTM，BIS，BS，AOAC等）的可追溯性。

At times it becomes cost prohibitive to procure the original standards so in such case reliable standards bearing traceability to original standards can be procured at a reasonable cost.

In short, calibration helps with making your measurement equipment more accurate according to the standards. In this way, you do not end up making any mistakes while carrying out any process. So your results are just as you want them to be, perfect. This is why calibration is important for different industries, and it must be carried out at specific intervals to avoid any trouble.

Calibration Frequency

It is necessary to calibrate all instruments and glassware before first use in the laboratory. Subsequently calibration is repeated as per intervals specified in the standard operating procedures on the basis of supplier recommendations. Outside the schedule calibration becomes necessary when an instrument is relocated even within the same laboratory, after a major repair or even if a new accessory is installed.

You should not worry about the cost associated with calibration because it is minimal in front of theimportance of calibration. As calibrated equipment will show more accurate results, you can easily cut out on further costs of making errors with this process. So it is more of an investment rather than an expenditure, and you must carry it out at specific intervals.

校准在哪里?

Most of the instruments can be calibrated in-house but some instruments need periodic calibration by the supplier representative or an. outside calibration laboratory which is accredited by NABL for the required purpose.

再一次需要calib校准有一些是简单的ration of output against a reference standard and there are others requiring calibration of different modules such as HPLC which requires separate calibration of light sources, pumps, injectors, etc. It becomes all the more important to keep record of all calibrations and such records should be preserved for time specified in SOP’s.

Who Can Calibrate?

Instrument calibration is authentic only if it is carried out by person(s) authorized by the laboratory or by a third party. The person calibrating an instrument should put his signatures both on the calibration sticker and the calibration records.

即使从一般意义上讲，校准也必须仅由专业人士或授权人员进行。否则，您将无法确保校准是否成功。因此，未能执行该过程的全部目的。

What to do if Instrument is Out of Calibration Validity?

Before using an instrument inspect its calibration sticker and ensure that it is within its calibration validity. If you find that the calibration date is over simply replace the calibration sticker with ‘ Instrument under Maintenance ‘ sticker and inform the concerned to complete the calibration before proceeding with its use.

Like instrument calibration the use of validated methods of analysis plays an equally important role and will be discussed in a subsequent article.

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